What we do:
Our research focuses on understanding the molecular mechanisms that govern G protein-coupled receptor (GPCR) function, to translate fundamental insights into innovative therapeutic strategies.We integrate functional assays, ligand profiling, receptor mutagenesis, and high-resolution cryo-EM studies to dissect critical protein-ligand and protein-protein interactions. By developing tailored molecular tools, including fluorescent probes and bivalent ligands, and pairing them with specialized test systems, we uncover how receptor dynamics shape signaling outcomes.
A central aspect of our work is the role of allosteric mechanisms in GPCR dimerization. These transient and reversible intramembrane interactions influence ligand binding, signal transduction, and receptor trafficking, offering new opportunities for pharmacological intervention. By targeting receptor dimerization and unconventional binding sites, we aim to develop next-generation therapeutics for neurodegenerative, psychiatric, and inflammatory diseases, advancing medicinal chemistry from molecular insights to clinical impact.
Currently, our research is directed toward three key areas:
- GPR3 — an orphan GPCR implicated in neurodegenerative disorders
- D2R–NTSR1 and D3R-NTSR1 heterodimers — interfaces relevant to neurotransmission in neuropsychiatric conditions
- TAS2R14 — a broadly tuned bitter taste receptor with emerging roles in inflammation