Research topics and selected publications:
Synthetic methods:
a) Visible-light mediated radical arylations using a fluorescein-derived diazonium salt: reactions proceeding via an intramolecular forth and back electron transfer
N. Diesendorf, P. Wenisch, J. Oppl, M. R. Heinrich, Org. Lett. 2023, 25, 76-81
b) Connecting ruthenium photocatalysis to 1,2-dioxetane-mediated chemiluminescence – a highly versatile novel combination for optical detection and read-out
J. Köckenberger, C. Sauer, R. Thurston, J. Oppl, M. R. Heinrich, Angew. Chem. Int. Ed. 2023
c) pH-Dependent conformational switching of amide bonds – from full trans to full cis and vice versa
R. Thurston, V. Zantop, K. S. Park, H. Maid, A. Seitz, M. R. Heinrich, Org. Lett. 2022, 24, 3488-34
d) Visible light promoted, catalyst-free radical carbohydroxylation and carboetherification under mild biomimetic conditions
L.-M. Altmann, V. Zantop, P. Wenisch, N. Diesendorf, M. R. Heinrich, Chem. Eur. J. 2021, 27, 2452-2462
Medicinal chemistry
a) Tuning the Polarity of Antibiotic-Cy5 Conjugates Enables Highly Selective Labeling of Binding Sites
F. Graßl, M. B. Konrad, J. Krüll, A. Pezerovic, L. Zähnle, A. Burkovski, M. R. Heinrich, Chem. Eur. J. 2023
b) Cyanine- and Rhodamine-Derived Alkynes for the Selective Targeting of Cancerous Mitochondria via Radical Thiol-Yne Coupling in Live Cells
J. Köckenberger, I. Klemt, C. Sauer, A. Arkhypov, V. Reshetnikov, A. Mokhir, M. R. Heinrich, Chem. Eur. J. 2023
c) Exploring structural determinants of bias among D4 subtype-selective dopamine receptor agonists
F. Graßl, L. Bock, A. H.-H. Gonzalez, M. Schiller, P. Gmeiner, J. König, M. F. Fromm, H. Hübner, M. R. Heinrich, J. Med. Chem. 2023, 66
d) Synthesis, characterization and application of muscarinergic M3 receptor ligands linked to fluorescent dyes
J. Köckenberger, O. Fischer, A. Konopa, S. Bergwinkl, S. Mühlich, P. Gmeiner, R. J. Kutta, H. Hübner, M. Keller, M. R. Heinrich, J.Med. Chem. 2022, 65, 16494-16509
e) Regiospecific introduction of halogens on the 2-aminobiphenyl subunit leads to highly potent and selective M3 muscarinic acetylcholine receptor antagonists and weak inverse agonists
O. Fischer, J. Hofmann, H. Rampp, G. Pratsch, A. Bartuschat, J. Kaindl, R. V. Taudte, M. F. Fromm, H. Hübner, P. Gmeiner, M. R. Heinrich, J. Med. Chem. 2020, 63, 4349-4369