Eichler Laboratory – Selected Publications
Filamin a binds deleted in liver cancer 1 (DLC1) to promote its tumor suppressor activity and inhibit the SRF coactivator MRTF-A
Sergeev, M., Meier, M.A., Wohlleben, P., Rupprecht, L., Kupraszewicz-Hutzler, M., Hilgers, K., Hartner, A., Voegele, A.L., Atreya, R., Frey, Y., Srirangan, S., Eichler, J., Confais, C., Hédan, B., Jarry, U., Olayioye, M.A., Muehlich, S.
Neoplasia, 71, 101258, 2026.
DOI: https://doi.org/10.1016/j.neo.2025.101258.
Investigation of the Interactions and pH-Dependent Structural Changes in Helical Peptides by Molecular Dynamics Simulations
Zurmühl, S., Horn, A., Leukel, S., Eichler, J., Castiglione, K., Sticht, H.
J. Phys. Chem. B, 2026.
Development and Characterization of a Human Papillomavirus-Based Nanoparticle Carrier for Heterologous Vaccine Antigens
Wang, Y., Bartelsen, N., Arnold, P., Müller-Schmucker, S. Weingärtner, C., Beutel, J. Eichler, J., Temchura, V., Damm, D. Überla, K.
Sci Rep 15, 32927, 2025.
DOI: https://doi.org/10.1038/s41598-025-19009-3
Versatile Features of an Antibody Mimetic Peptide and Its Variants
Dolles, S., Leukel, S., Gensberger-Reigl, S., Rohrhofer, A., Rauch-Wirth, L., Kaygisiz, K., Synatschke, C., Münch, J., Schmidt, B., Pischetsrieder, M., Eichler, J.
Journal of PeptideScience , 31:e70005 2025.
DOI: 10.1002/psc.70005
Oriented display of HIV-1 Env trimers by a novel coupling strategy enhances B cell activation and phagocytosis
Di Vincenzo, R., Beutel, J., Arnold, P., Wang, Y., Damm, D., Tannig, P., Lux, A., Temchura, V., Eichler, J. and Überla, K.
Front.Immunol. , 8(15), 1344346 2024.
DOI: 10.3389/fimmu.2024.1344346
Bind&Bite: Covalently stabilized heterodimeric coiled-coil peptides for the site-selective, cysteine-free chemical modification of proteins
Beutel, J., Tannig, P., Di Vincenzo, R., Schumacher, T., Überla, K. and Eichler, J.
RSC Chemical Biology , 4, 794 – 803 2023.
DOI: 10.1039/D3CB00122A
Computational Characterization of the Binding Properties of the HIV1-Neutralizing Antibody PG16 and Design of PG16-Derived CDRH3 Peptides
Deubler, M., Weißenborn, L., Leukel, S., Horn, A., Eichler, J., Sticht, H.
Biology , 12(6):824. 2023.
A Peptide Inhibitor of the Human Cytomegalovirus Core Nuclear Egress Complex
Alkhashrom S, Kicuntod J, Stillger K, Lützenburg T, Anzenhofer C, Neundorf I, Marschall M, Eichler J.
Pharmaceuticals, 15(9):1040. 2022.
DOI: 10.3390/ph15091040
Smaller, Stronger, More Stable: Peptide Variants of a SARS-CoV-2 Neutralizing Miniprotein
Weißenborn L, Richel E, Hüseman H, Welzer J, Beck S, Schäfer S, Sticht H, Überla K, Eichler J
Int J Mol Sci,, 23(11):6309. 2022
DOI: 10.3390/ijms23116309
The crystal structure of the varicella-zoster Orf24-Orf27 nuclear egress complex spotlights multiple determinants of herpesvirus subfamily specificity
Schweininger, J., Kriegel, M., Häge, S., Conrad, M., Alkhashrom, S., Lösing, J., Weiler, S., Tillmanns, J., Egerer-Sieber, C., Decker, A., Lenac Roviš, T., Eichler, J., Sticht, H., Marschall, M., & Muller, YA.
Journal of Biological Chemistry, 101625. 2022.
DOI: 10.1016/j.jbc.2022.101625
A novel D-amino acid peptide with therapeutic potential (ISAD1) inhibits aggregation of neurotoxic disease-relevant mutant Tau and prevents Tau toxicity in vitro
Aillaud, I., Kaniyappan, S., Chandupatla, R. R., Ramirez, L. M., Alkhashrom, S., Eichler, J., Horn, A., Zweckstetter, M., Mandelkow, E., Sticht, H., & Funke, S. A.
Alzheimer’s research & therapy, 14(1), 15. 2022.
DOI: 10.1186/s13195-022-00959-z
A PROSS-designed extensively mutated estrogen receptor α variant displays enhanced thermal stability while retaining native allosteric regulation and structure
Kriegel M, Wiederanders HJ, Alkhashrom S, Eichler J, Muller YA.
Sci Rep. 2021.
DOI: 10.1038/s41598-021-89785-1
Exploring the Human Cytomegalovirus Core Nuclear Egress Complex as a Novel Antiviral Target: A New Type of Small Molecule Inhibitors
Alkhashrom, S., Kicuntod, J., Häge, S., Schweininger, J., Muller, Y. A., Lischka, P., Marschall, M., & Eichler, J.
Viruses, 2021.
DOI: 10.3390/v13030471
Properties of Oligomeric Interaction of the Cytomegalovirus Core Nuclear Egress Complex (NEC) and Its Sensitivity to an NEC Inhibitory Small Molecule
Kicuntod, J., Alkhashrom, S., Häge, S., Diewald, B., Müller, R., Hahn, F., Lischka, P., Sticht, H., Eichler, J., & Marschall, M.
Viruses, 2021.
DOI: 10.3390/v13030462
Exploring Viral Interference Using Peptides: Molecular Determinants of HIV-1 Inhibition by a Peptide Derived from Human Pegivirus-1 Envelope Protein E2
Hoffmann, R., Ruegamer, T., Schaubacher, J., Rohrhofer, A., Kirmess, P., Fiebig, K. M., Schmidt, B. and Eichler, J.
ChemMedChem 2020.
Nuclear Egress Complexes of HCMV and Other Herpesviruses: Solving the Puzzle of Sequence Coevolution, Conserved Structures and Subfamily-Spanning Binding Properties
Marschall, M., Hage, S., Conrad, M., Alkhashrom, S., Kicuntod, J., Schweininger, J., Kriegel, M., Losing, J., Tillmanns, J., Neipel, F., Eichler, J., Muller, Y. A. and Sticht, H.
Viruses 2020.
DOI: 10.3390/v12060683
High-resolution crystal structures of two prototypical beta- and gamma-herpesviral nuclear egress complexes unravel the determinants of subfamily specificity
Muller, Y. A., Hage, S., Alkhashrom, S., Hollriegl, T., Weigert, S., Dolles, S., Hof, K., Walzer, S. A., Egerer-Sieber, C., Conrad, M., Holst, S., Losing, J., Sonntag, E., Sticht, H., Eichler, J. and Marschall,M.
J Biol Chem 2020.
Untargeted Proteomics-Based Profiling for the Identification of Novel Processing-Induced Protein Modifications in Milk
Meltretter, J., Wust, J., Dittrich, D., Lach, J., Ludwig, J., Eichler, J. and Pischetsrieder, M.
J Proteome Res 2020.
DOI: 10.1021/acs.jproteome.9b00630
Inhibition of HIV-1 infection by HPgV-1 derived peptides is affected by HPgV-1 genotype and HIV-1 coreceptor tropism
Ruegamer, T.; Hoffmann, R.; Rohrhofer, A.; Audebert, F., Salzberger, B.; Korn, K.; Schuster, P.; Eichler, J.; Schmidt, B.
Aids 2018
DOI: 10.1097/QAD.0000000000001926
The Hard Way towards an Antibody-Based HIV-1 Env Vaccine: Lessons from Other Viruses
Ringel, O.; Vieillard, V.; Debré, P.; Eichler, J.; Büning, H.; Dietrich, U.
Viruses 2018, 10, 197.
DOI: 10.3390/v10040197
Synthetic antibody mimics for the inhibition of protein – ligand interactions
Haußner, C.; Lach, J.; Eichler, J.
Curr.Opin.Chem.Biol. 2017, 40, 72-77.
DOI: 10.1016/j.cbpa.2017.07.001
The diversity and utility of amyloid fibrils formed by short amyloidogenic peptides
Al-Garawi, Z.S.; Morris, K.L.; Marshall, K.W.; Eichler, J.; Serpell, L.C.
Interface Focus 2017, 7:20170027.
Peptide Paratope Mimics of the broadly neutralizing HIV-1 Antibody b12
Haußner, C.; Damm, D.; Nirschl, S.; Rohrhofer, A.; Schmidt, B.; Eichler, J.
ChemBioChem 2017, 18, 647-653.
Systematic analysis of phosphotyrosine antibodies recognizing single phosphorylated EPIYA-motifs in CagA of East Asian-type Helicobacter pylori strains
Lind, A.; Backert, S.; Hoffmann, R.; Eichler, J.; Yamaoka, Y.; Perez-Perez, G.I.; Torres, J.; Sticht, H.; Tegtmeyer, N.
BMC Microbiology 2016, 16:201.
DOI: 10.1186/s12866-016-0820-6
Synthetic Peptides as Protein Mimics
Groß, A.; Hashimoto, C.; Sticht, H.;Eichler, J.
Front.Bioeng.Biotechnol. 2016, 3:211.
A monosaccharide residue is sufficient to maintain mouse and human IgG subclass activity and directs IgG effector functions to cellular Fc-receptors
Kao, D.; Danzer, H.; Collin, M.; Groß, A.; Eichler, J.; Stambuk, J.; Lauc, G.; Lux, A.; Nimmerjahn, J.
Cell Reports 2015, 13, 2376-2385.
DOI: 10.1016/j.celrep.2015.11.027
Virtual screening of a milk peptide database for the identification of food-derived antimicrobial peptides
Liu, Y.; Eichler, J.;Pischetsrieder, M.
Mol.Nutr.Food Res. 2015, 59, 2243-2254.
Synthetic peptides mimicking the binding site of human acetylcholinesterase for its inhibitor fasciculin 2
Kafurke, U.; Erijman, A.; Aizner, Y.; Shifman, J.M.; Eichler, J.
J.Peptide Sci. 2015, 21, 723-730.
DOI: 10.1002/psc.2797
Turning peptide ligands into small-molecule inhibitors of protein-protein interactions
Hashimoto, C.; Eichler, J.
ChemBioChem 2015, 16, 1855-1856.
Ligand selectivity of a synthetic CXCR4 mimic
Groß, A.; Brox, R.; Damm, D.; Tschammer, N.; Schmidt, B.; Eichler, J.
Bioorg.Med.Chem. 2015, 23, 4050-4055.
DOI: 10.1016/j.bmc.2015.03.003
Enhancement and induction of HIV-1 infection through an assembled peptide derived from envelope glycoprotein gp120
Groß, A.; Rödel, K.; Kneidl, B.; Donhauser, N.; Mössl, M.; Lump, E.; Münch, J.; Schmidt, B.; Eichler, J.
ChemBioChem 2015, 16, 446-454.
Influence of Nonenzymatic Posttranslational Modifications on Constitution, Oligomerization and Receptor Binding of S100A12
Augner, K.; Eichler, J.; Utz, W.; Pischetsrieder, M.
PLoS One 2014.
DOI: 10.1371/journal.pone.0113418
Versatile trivalent C3-symmetric scaffolds and their use for covalent stabilization of the foldon trimer
Berthelmann, A.; Lach, J.; Gräwert M.A.; Groll, M.; Eichler
J. Org.Biomol.Chem. 2014, 12(16), 2606-2614.
DOI: 10.1039/C3OB42251H
Mimicking protein-protein interactions through peptide-peptide interactions: HIV-1 gp120 and CXCR4
Groß, A.; Möbius, K.; Haußner, C.; Donhauser, N.; Schmidt, B.; Eichler, J.
Frontiers in Immunology 2013.
Identification of a Novel TGF-β-Binding Site in the Zona Pellucida C-terminal (ZP-C) Domain of TGF-β-Receptor-3 (TGFR-3)
Diestel, U.; Resch, M.; Meinhardt, K.; Weiler, S.; Hellmann, T.V.; Mueller, T.D.; Nickel, J.; Eichler, J.; Muller, Y.A.
PLoS One 2013, 8(6), e67214.
DOI: 10.1371/journal.pone.0067214
HIV-1 Fusion Is Blocked through Binding of GB Virus C E2D Peptides to the HIV-1 gp41 Disulfide Loop
Eissmann, K.; Mueller, S.; Sticht, H.; Jung, S.; Zou, P.; Jiang, S.; Groß, A.; Eichler, J.; Fleckenstein, B.; Reil, H.
PLOSone 2013, 8 (1), e54452.
DOI: 10.1371/journal.pone.0054452
Peptides presenting the binding site of human CD4 for the HIV-1 envelope glycoprotein gp120
Meier, J.; Kassler, K.; Sticht, H.; Eichler, J.
Beilstein J.Org.Chem.2012 8, 1858-1866, 2012.
DOI: 10.3762/bjoc.8.214
Exploring Converse Molecular Mechanisms of anti-HIV-1 Antibodies Using a Synthetic CXCR4 Mimic
Haußner, C.; Möbius, K.; Eichler, J.
Bioorg.Med.Chem.Lett. 2012, 22, 6099-6102.
DOI: 10.1016/j.bmcl.2012.08.035
The nuclear import of isoforms of the cytomegalovirus kinase pUL97 is mediated by differential activity of NLS1 and NLS2 both acting
through classical importin α binding
Webel, R.; Solbak, S.M.Ø.; Held, C.; Milbradt, C.; Groß, A.; Eichler, J.; Wittenberg, T.; Jardin, C.; Sticht, H.; Fossen, T.; Marschall, M.
J.Gen.Virol. 2012, 93, 1756-1768.
A Functionally Selective Synthetic Mimic of the HIV-1 Coreceptor CXCR4
Möbius, K.; Dürr, R.; Haußner, C.; Dietrich, U.; Eichler, J.
Chem.Eur.J. 2012, 18, 8292-8295.
Structural basis for Species Selectivity in the HIV-1 gp120 – CD4 interaction: Restoring affinity to gp120 in murine CD4 mimetic peptides
Kassler, K.; Meier, J.; Eichler, J.; Sticht, H.
Adv.Bioinformatics 2011, Volume 2011, Article ID 736593.
DOI: 10.1155/2011/736593
Differential Downregulation of ACE2 by Spike Proteins of Severe Acute Respiratory Syndrome Coronavirus and Human Coronavirus NL63
Glowacka, I.; Bertram, S.; Herzog, P.; Pfefferle, S.; Steffen, I.; Muench, M.O.; Simmons, G.; Hofmann, H.; Kuri, T.; Weber, F.; Eichler, J.;
Drosten, C.; Pöhlmann, S.
J.Virol. 2010, 84, 1198-1205.
DOI: 10.1128/JVI.01248-09
Peptide ligands selected with CD4-induced epitopes on native dualtropic HIV-1 envelope proteinsmimic extracellular coreceptor domains and bind to HIV-1 gp120 independently of coreceptor usage
Dervillez, X.; Klaukien, V.; Dürr, R.; Koch, J.; Kreutz, A.; Haarmann, T.; Stoll, M.; Lee, D.; Carlomagno, T.; Schnierle, B.; Möbius, K.; Königs, C.;
Griesinger, C.; Dietrich, U.
J.Virol. 2010, 84, 10131-10138.
DOI: 10.1128/JVI.00165-10
HIV-derived peptide mimics
Möbius, K.; Eichler, J.
Drug Discovery Today: Technologies 2009, 6 (1-4), e19-e25.
DOI: 10.1016/j.ddtec.2009.09.001
The solution structure of pGolemi, a high affinity Mena EVH1 binding miniature protein, suggests explanations for
paralog-specific binding to Ena/VASP homology (EVH) 1 domains
Link, N.M.; Hunke, C.; Mueller, J.W.; Eichler, J.; Bayer, P.
Biol.Chem. 2009 390 (5-6),417-426.
DOI: 10.1515/BC.2009.045
Peptides as protein binding site mimetics
Eichler, J.
Curr.Opin.Chem.Biol. 2008 12, 707-713.
DOI: 10.1016/j.cbpa.2008.09.023
Synthetic Mimetics of the gp130 Binding Site for Viral Interleukin-6 as Inhibitors of the vIL-6 – gp130 Interaction
Sudarman, E.; Bollati-Fogolin, M.; Hafner, M.; Müller, W.; Scheller, J.; Rose-John, S.; Eichler, J.
Chem.Biol.Drug Des. 2008, 71, 494-500.
DOI: 10.1111/j.1747-0285.2008.00649.x
Structural/Functional Mimicry of the Binding Site of hYAP-WW Domain for Proline-Rich Ligands
Strijowski, U.; Hirsch, T.; Quintilla, A.; Wenzel, W.; Eichler, J.
Int.J.Peptide Res.Therap. 2007, 13(1-2),245-250.
DOI: 10.1007/s10989-006-9074-8
Synthetic Mimetics of the CD4 Binding Site of HIV-1 gp120 for the Design of Immunogens
Franke, R.; Hirsch, T.; Overwin, H.; Eichler, J.
Angew.Chem. 2007 119(8), 1275-1277 (Int.Ed. 46(8), 1253-1255).
ProteomeBinders: planning a European resource of affinity reagents for analysis of the human proteome
Taussig, M.J.; Stoevesandt, O.; Borrebaeck, C.A.K.; Bradbury, A.R.; Cahill, D.; Cambillau, C.; de Daruvar, A.; Dübel, S.; Eichler, J.; Frank, R.;
Gibson, T.J.; Gloriam, D.; Gold, T.; Herberg, F.W.; Hermjakob, H.; Hoheisel, J.D.; Joos, T.O.; Kallioniemi. O.; Koegll, M.; Konthur, Z.; Korn, B.;
Kremmer, E.; Krobitsch, S.; Landegren,U.; van der Maarel, S.; McCafferty, J.; Muyldermans, S.; Nygren, P.A.; Palcy, S.; Plückthun, A.; Polic, B.;
Przybylski, M.;Saviranta, P.; Sawyer, A.; Sherman, D.J.; Skerra, A.; Templin, M.; Ueffing, M.; Uhlén, M.
Nature Methods 2007 4, 13-17.
A Rationally Designed Synthetic Mimic of the Discontinuous CD4 Binding Site of HIV-1 gp120
Franke, R.; Hirsch, T.; Eichler, J.
J.Recept.Sig.Transd. 2006, 26, 453-460.
DOI: 10.1080/10799890600923179
Abrogation of vIL-6 induced signaling by intracellular retention and neutralization of vIL-6 with an anti vIL-6 single-chain antibody selected by phage display
Kovaleva, M.; Bußmeyer, I.; Rabe1, B.; Sudarman, E.; Eichler, J.; Conrad, U.; Rose-John, S.; Scheller, J.
J.Virolol. 2006, 80, 8510-8520.
Structure-Based Synthetic Mimicry of Discontinuous Protein Binding Sites: Inhibitors of the Interaction of Mena EVH1 Domain with Proline-Rich Ligands
Hunke, C.; Hirsch, T.; Eichler, J.
ChemBioChem 2006, 7(8), 1258-1264.
Forced dimerization of gp130 leads to constitutive STAT3 activation, cytokine independent growth and blockade of differentiation of embryonic stem cells
Stuhlmann-Laisz, C.; Lang, S.; Chalaris, A.; Sudarman, E.; Eichler, J.; Klingmüller, U.; Samuel, M.; Ernst, M.; Rose-John, S.; Scheller, J.
Molecular Biology of the Cell 2006, 17, 2986-2995.
Peptide ligation through click chemistry for the generation of assembled and scaffolded peptides
Franke, R.; Doll, C.; Eichler, J.
Tetrahedron Lett. 2005, 46(26), 4479-4482.
DOI:10.1016/j.tetlet.2005.04.107
Synthetic Peptide Arrays and Peptide Combinatorial Libraries for the Exploration of Protein-Protein Interactions and the Design of Protein Inhibitors
Eichler, J.
Comb.Chem.High Throughput Screen. 2005,8(2), 135-143.
Post-Genomic Chemistry
Varfolomeyev, S.; Efremenko, E.; Beletskaya, I.; Bertini, I.; Blackburn, G.M.; Bogdanov, A.; Cunin, R.; Eichler, J.; Galaev, I.; Gladyshev, V.;
O’Hagan, D.; Haertle, T.; Jarv, J.; Karyakin, A.; Kurochkin, I.; Mikolajczyk, M.; Poroikov, V.; Sakharov, I.; Spener, F.; Voyer, N.; Wild, J.
Pure Appl.Chem. 2005, 77(9): 1641-1654.
Loops on Loops: Generation of Complex Scaffolded Peptides Presenting Multiple Cyclic Fragments
Franke, R.; Doll, C.; Wray V.; Eichler, J.
Org.Biomol.Chem. 2004, 2(19): 2847-2851.
DOI: 10.1039/b403720k
Development of a monoclonal antibody-based immunoabsorbent assay for the binding of gp130 to the IL-6/IL-6R complex and its competitive inhibition
Scheller, J.; Kovaleva, M.; Rabe, B.; Eichler, J.; Kallen, K.J.; Rose-John, S.
J.Immunol.Methods 2004, 291(1-2): 93-100, 2004.
DOI: 10.1016/j.jim.2004.05.002
Rational and Random Strategies for the Mimicry of Discontinuous Protein Binding Sites
Eichler, J.
Protein Peptide Lett. 2004, 11(4): 281-290, 2004.